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Baidu Releases ERNIE-4.5-VL-28B-A3B-Thinking: An Open-Source and Compact Multimodal Reasoning Model Under the ERNIE-4.5 Family

How can we get large model level multimodal reasoning for documents, charts and videos while running only a 3B class model in production? Baidu has added a new model to the ERNIE-4.5 open source family. ERNIE-4.5-VL-28B-A3B-Thinking is a vision language model that focuses on document, chart and video understanding with a small active parameter budget.…

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AlphaFold: Five Years of Impact

Increasing speed of discovery Cyril Zipfel, professor of Molecular & Cellular Plant Physiology at the University of Zurich and Sainsbury Lab, saw research timelines shrink drastically. They used AlphaFold alongside comparative genomics to better understand how plants perceive changes in their environment, paving the way for more resilient crops. AlphaFold has been cited in more…

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A Coding Guide to Implement Advanced Hyperparameter Optimization with Optuna using Pruning Multi-Objective Search, Early Stopping, and Deep Visual Analysis

In this tutorial, we implement an advanced Optuna workflow that systematically explores pruning, multi-objective optimization, custom callbacks, and rich visualization. Through each snippet, we see how Optuna helps us shape smarter search spaces, speed up experiments, and extract insights that guide model improvement. We work with real datasets, design efficient search strategies, and analyze trial…

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